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The Mail Tip indicates the recipient to which the sender isn't allowed to send messages and gives the sender the option to remove the recipient from the message.It also clearly informs the sender that the message won't be delivered if sent.
However, if the remote domain isn't configured as an internal domain, the internal automatic reply is returned to all users whose mailboxes are in the local domain and the external automatic reply is returned to users whose mailboxes are in the remote domain.
For example, you can create a custom Mail Tip for a distribution group explaining its purpose to reduce its misuse.
By default, custom Mail Tips aren't displayed if the sender isn't allowed to send to that recipient.
A custom Mail Tip is displayed if the sender adds a recipient for whom a customized Mail Tip is configured.
A custom Mail Tip can be useful for providing specific information about a recipient.